![]() 7, 9, 13Ĭurcumin has a chemical structure similar to that of Congo red and binds to the beta‐pleated sheets in Aβ aggregates with high affinity and specificity. 17, 23 One of the contemporary imaging modalities is curcumin‐enhanced retinal fluorescence imaging that was pioneered as a useful non‐invasive tool for retinal Aβ plaque detection in animals and humans. 7, 13, 16, 17, 18, 19 Modern technology was recently developed to image retinal amyloidosis in patients with AD, 13, 20, 21, 22 as fluorescence signal and other retinal features may aid in predicting cerebral amyloid status. ![]() 7, 8, 9, 10, 11, 12, 13, 14, 15 Clinical and preclinical data support that retinal Aβ deposition correlates with and may even precede cerebral Aβ deposition. Increased Aβ burden and Aβ deposits were also identified in the human AD retina, a central nervous system (CNS) tissue that has the advantage of increased accessibility for direct non‐invasive visualization. 4 Surrogate markers of brain Aβ amyloidosis include reductions in Aβ 42 levels in the cerebrospinal fluid (CSF) and increased amyloid tracer retention on positron emission tomography (PET) imaging. 2 Aβ is a pathological hallmark of AD, the target of disease‐modifying therapies, 3 and useful in discriminating AD from other neuropathologies. 1 Considerable evidence supports that quantitative imaging of biofluid biomarkers of AD pathology, amyloid beta (Aβ), tau, and neurodegeneration, may be useful predictors of subsequent cognitive decline. Alzheimer's disease (AD) is a devastating neurodegenerative disorder and the most prevalent form of dementia, associated with enormous social and public health challenges.
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